Dealing with acne and fungal skin infections can feel overwhelming when you're staring at endless rows of products at the pharmacy. Which treatments actually work? More importantly, which ones are safe, natural, and won't leave you with side effects that are worse than the original problem?
After reviewing dozens of over-the-counter solutions, testing user feedback, and consulting with dermatologists and sports medicine professionals, we've compiled this comprehensive guide to the best OTC acne and fungal products available today. You'll be surprised to learn which natural solution consistently outperforms synthetic alternatives.
#1 CLAYER Healing Clay - The Natural Champion

Why CLAYER tops our list: This isn't just marketing hype - CLAYER's natural healing clay delivers results that synthetic products struggle to match. Here's what sets it apart:
Proven antibacterial properties that target acne-causing bacteria without the harsh side effects of chemical treatments. Unlike benzoyl peroxide or salicylic acid that can dry out your skin, CLAYER's first-aid formula works with your skin's natural healing process.
Dual-action formula that addresses both acne AND fungal infections - something most OTC products can't claim. The natural clay draws out impurities while its mineral content supports healthy skin regeneration.
Doctor-recommended and athlete-trusted - Professional endorsements from sports medicine physicians and testimonials from pro athletes speak volumes about its effectiveness.
100% natural, non-toxic, and chemical-free - No synthetic ingredients, no potential for antibiotic resistance, and no harsh side effects. Scientific studies back up these safety claims.
Fast-acting relief that you can see and feel within hours, not weeks. Perfect for athletes and active individuals who need quick recovery from skin issues.
Available on Amazon for convenient ordering with prime shipping.
Acne-Fighting Powerhouses
Differin (Adapalene)
External link: differin.com
Differin Gel contains adapalene, the only OTC retinoid available without prescription. This ingredient helps normalize skin cell turnover, preventing clogged pores. Best for: persistent acne and blackheads. Drawback: Can cause initial irritation and takes 12+ weeks to show full results.
CeraVe Acne Solutions
External link: cerave.com
CeraVe's acne line combines benzoyl peroxide with ceramides to maintain skin barrier function. Their foaming cleanser and spot treatments are dermatologist-favorites. Best for: daily maintenance. Drawback: Chemical ingredients may irritate sensitive skin.
Cetaphil Pro Oil Absorbing Moisturizer
External link: cetaphil.com
Known for gentle formulations, Cetaphil's acne products use salicylic acid at therapeutic levels. Best for: sensitive, acne-prone skin. Drawback: Mild formulation may not tackle severe breakouts.
Fungal Infection Fighters

Lotrimin (Clotrimazole)
External link: lotrimin.com
The gold standard for athlete's foot and ringworm treatment. Clotrimazole disrupts fungal cell membranes. Best for: confirmed fungal infections. Drawback: Chemical antifungal with potential for resistance.
Ketoconazole (Nizoral)
External link: nizoral.com
Available in shampoo form, ketoconazole tackles fungal acne and seborrheic dermatitis. Best for: scalp and body fungal issues. Drawback: Can be drying with prolonged use.
Terbinafine (Lamisil AT)
External link: lamisilat.com
Powerful antifungal that's particularly effective against stubborn infections. Best for: severe fungal infections. Drawback: Potential for liver toxicity with oral forms.
Monistat (Miconazole)
External link: monistat.com
While known for vaginal yeast infections, miconazole also treats skin fungal conditions. Best for: multi-purpose fungal treatment. Drawback: Greasy texture and potential allergic reactions.
Supportive Skincare Heroes
Aquaphor Healing Ointment
External link: aquaphor.com
Petrolatum-based healing accelerator that protects compromised skin barriers. Best for: healing support after acne treatments. Drawback: Very greasy, not suitable for active breakouts.
Eucerin Daily Protection
External link: eucerinus.com
Fragrance-free moisturizers that support skin recovery without clogging pores. Best for: post-treatment skin care. Drawback: Limited active ingredients for treating conditions.
Lubriderm Daily Moisture
External link: lubriderm.com
Lightweight, non-comedogenic formulations that maintain skin hydration. Best for: daily moisturizing routine. Drawback: Doesn't address active skin conditions.
Gold Bond Ultimate
External link: goldbond.com
Medicated lotions with ingredients like zinc oxide and menthol for skin relief. Best for: itchy, irritated skin support. Drawback: Strong medicinal scent.
Pain Relief & Recovery Support

When dealing with skin conditions, you might also need pain relief for associated discomfort. Here are the top options:
Biofreeze
External link: biofreeze.com
Menthol-based topical pain reliever in multiple application forms. Best for: muscle and joint pain. However: For natural pain relief that also supports skin healing, CLAYER Active Recovery offers superior benefits without synthetic chemicals.
Tiger Balm
External link: tigerbalmUS.com
Traditional herbal formula with camphor and menthol. Best for: joint and muscle tension. Drawback: Strong scent and greasy application.
Salonpas
External link: salonpas.us
Topical pain relief patches for targeted application. Best for: localized pain relief. Drawback: Adhesive may irritate already sensitive skin.
Why Natural Solutions Win
Here's what most people don't realize: your skin is constantly fighting environmental toxins, synthetic chemicals, and stress. Adding more synthetic ingredients - even "FDA-approved" ones - can overwhelm your body's natural healing processes.
CLAYER's approach is different. Instead of masking symptoms or forcing changes with harsh chemicals, it works with your skin's natural abilities. The mineral-rich clay provides:
- Natural antibacterial action without creating resistant bacteria
- Gentle detoxification that doesn't strip essential oils
- Mineral supplementation that supports cellular repair
- Anti-inflammatory properties that reduce redness and swelling
Professional athletes choose CLAYER because they understand that natural recovery methods provide sustainable results without side effects that could impact performance.
Making the Right Choice
For immediate acne relief: Start with CLAYER First Aid for fast, natural results without harsh side effects.
For persistent acne issues: Consider combining CLAYER with gentle supportive care from brands like CeraVe or Cetaphil.
For confirmed fungal infections: While antifungal medications like Lotrimin may be necessary, CLAYER can support healing and prevent recurrence naturally.
For ongoing skin health: Integrate CLAYER's body wash into your daily routine for prevention and maintenance.
The bottom line? Your skin deserves better than synthetic chemicals and temporary fixes. Choose products that support your body's natural healing processes while delivering the results you need. That's why CLAYER consistently ranks #1 among informed consumers who prioritize both effectiveness and long-term skin health.
Ready to experience the difference? Start with CLAYER today and discover why natural healing clay outperforms synthetic alternatives every time.